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Garlic Extract Modulates Endothelial Function in Obesity

10/30/2018 2:05:18 PM
Obesity-related chronic inflammation is marked by elevated levels of high-sensitivity C-reactive protein (hs-CRP) and pro-inflammatory cytokines. These mediators adversely affect endothelial function by raising levels of endothelial-derived compounds, like plasminogen activator inhibitor 1 (PAI-1). Higher PAI-1 is correlated with other markers of endothelial dysfunction, such as increased intima media thickness and arterial stiffness index.
Garlic (Allium sativum) has demonstrated antiplatelet, fibrinolytic, antithrombotic, and anti-inflammatory effects in both in vitro and in vivo studies. The current study evaluated the effects of garlic on markers of inflammation and endothelial function in obese subjects.
This 3-month, randomized, controlled trial involved 92 obese subjects. Participants were randomized to take a placebo or odorless extract of garlic (Garlicin, Olimp Laboratories, Poland), standardized to 2% allicin and dosed at 400 mg per day. The primary outcomes were serum blood levels of hs-CRP and PAI-1. Secondary outcomes were arterial stiffness index, blood pressure, lipid profile, and total antioxidant status.
From baseline to 3-months and compared to placebo, participants taking garlic extract experienced significantly reduced body weight and body mass index (BMI). Compared with placebo, garlic extract significantly lowered hsCRP, PAI-1, arterial stiffness index, and LDL-cholesterol. Also compared with placebo, garlic extract significantly increased total antioxidant status.

The authors of this study conclude that garlic extract favorably modifies biomarkers of endothelial function that are associated with cardiovascular risk. Garlic extract may be a reasonable way to modulate systemic inflammation, support endothelial function, and reduce the risk of chronic disease in patients with obesity.  
Szulińska M, Kręgielska-Narożna M, Świątek J et al. Garlic extract favorably modifies markers of endothelial function in obese patients -randomized double blind placebo-controlled nutritional intervention. Biomed Pharmacother. 2018; 102: 792-797.

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