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Antioxidants Modify the Relationship Between Short Sleep and Obesity

11/14/2017 11:07:33 AM
Short sleep duration and poor diet have independently been associated with obesity, but little is known about the interaction between these 2 variables. A study published by Doo and Kim in Nutrients (2017) examined how the effect of sleep duration on obesity might be modified by consumption of dietary antioxidants.
 
The cross-sectional study examined data from 3941 Korean men, aged 40-69 years, participating in the Korean Genome and Epidemiology Study (KoGES). Sleep duration was determined by a patient questionnaire. Short sleep duration was defined as ≤6 hours per day, and optimal sleep duration was defined as ≥7 hours per day. Consumption of dietary antioxidants was assessed by a validated food frequency questionnaire.
 
After adjusting for confounding variables, men with short sleep duration had a significantly higher risk of obesity (odds ratio=1.467; 95% CI, 1.282-1.678; p<.001) than men with optimal sleep duration. In the subgroup of men with short sleep duration, low consumption of dietary antioxidants significantly increased the odds of obesity. When compared with men with optimal sleep duration and high antioxidant consumption, the odds ratio for obesity was 1.429 in men with short sleep duration and high vitamin A consumption but 1.503 in men with short sleep duration and low vitamin A consumption. Similar trends were observed for consumption of retinol, carotene, vitamin C, and vitamin E. In contrast, antioxidant consumption had no effect on obesity risk in men who slept ≥7 hours per day.
 
Previous studies have suggested that short sleep duration might promote obesity by leading to increased appetite, subjective hunger, higher levels of ghrelin (a hunger hormone), and lower levels of leptin (a satiety hormone). The current study suggests that the increased odds of obesity related to short sleep duration could potentially be modified by higher consumption of dietary antioxidants. 
 
Reference: Doo M, Kim Y. The Consumption of Dietary Antioxidant Vitamins Modifies the Risk of Obesity among Korean Men with Short Sleep Duration. Nutrients. 2017;9(7).