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Silymarin Improves Metabolic Parameters of Type 2 Diabetes

7/24/2018 4:05:38 PM
Silybum marianum (milk thistle) seed has a long tradition of use to support liver and gastrointestinal health. Silymarin is a standardized extract of milk thistle seeds, which contains antioxidant and anti-inflammatory constituents. Because oxidative stress plays a role in the pathophysiology of type 2 diabetes, it is biologically plausible that silymarin might improve the metabolic parameters of this disease.
 
Researchers conducted a randomized controlled trial to explore the effects of silymarin on glycemic control and lipid profiles of patients with type 2 diabetes. A total of 40 patients (with type 2 diabetes and taking oral hypoglycemic medications) were randomized to take silymarin or placebo for 45 days. Silymarin (Livergol, manufactured by Goldaru Herbal Products Pharmaceutical Company in Iran) was standardized to 8.44% silymarin and 30.07% silybins and was dosed at 140 mg 3 times per day.
 
Results showed that silymarin significantly lowered fasting blood sugar, insulin, and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) and increased quantitative insulin sensitivity check index (QUICKI) in the intervention group as compared with baseline and placebo. In the intervention group, fasting blood sugar decreased by 11%, insulin decreased by 14 %, HOMA-IR decreased by 26%, and QUICKI increased by 6% after 45 days.   
 
Results also showed that silymarin significantly reduced triglycerides and the triglyceride to HDL-cholesterol ratio and enhanced HDL-cholesterol as compared with placebo. Silymarin also significantly reduced total cholesterol and LDL-cholesterol as compared with baseline. In the intervention group, triglycerides decreased by 24%, total cholesterol decreased by 8%, LDL-cholesterol decreased by 7%, the triglyceride to HDL-cholesterol ratio decreased by 28%, and HDL-cholesterol increased by 7%.
 
Potential mechanisms to explain the effects of silymarin on glycemic control and lipid profiles include its ability to inhibit hepatic glucose production, inhibit fatty acid synthesis, block cholesterol absorption, and increase fatty acid oxidation via peroxisome proliferator-activated receptor alpha (PPAR alpha). It is also possible that the antioxidant effects of silymarin support glycemic control.
 
Although the mechanisms are not entirely understood, the results of this study suggest that silymarin supports glycemic control and metabolic function when given as adjunctive therapy with oral hypoglycemic medications in type 2 diabetes.      
 
Reference
Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018; 44: 39-44.

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